WASHINGTON (AP) — When GOP presumptive presidential nominee Donald Trump was “pro-choice in every respect,” Indiana Gov. Mike Pence compared abortion to the tragedy of the Sept. 11 terrorist attacks.

When Pence opposed providing gay Americans with the protection of anti-discrimination laws, Trump declared that the Equal Employment Opportunity Commission needed to protect gay rights in the workplace.

And when Trump was applauding state lawsuits against big tobacco companies, Pence declared that “smoking doesn’t kill.”

Over the past two decades, the presumptive Republican presidential nominee has disagreed with his vice-presidential pick on plenty of political issues, including immigration policy, entitlement programs and trade. On social issues above all, Trump and Pence arrive at the 2016 general election from very different paths.