The debate will begin at 6 p.m. in the Wiekamp Hall Auditorium and is scheduled to last about 90 minutes. Audience members will have a chance to submit questions on notecards.
Buttigieg, a Democrat and South Bend native, has been mayor since 2012. Jones is also a South Bend native and is a newcomer to politics.
Questions and comments posted on Periscope will not receive a response so as to not interrupt the debate.
You can also follow @953MNC on Twitter for live coverage of the debate.
Anyone who attends the event is asked not to wear clothes, buttons, hats or other items that support a particular candidate or campaign.