INDIANAPOLIS (AP) — Indiana Lt. Gov. Sue Ellspermann is serving her final hours in office before her resignation takes effect in an unusual replacement of Republican Gov. Mike Pence’s running mate for his re-election campaign this year.

Ellspermann’s resignation becomes official at 5 p.m. Wednesday, about three weeks after she said she would step down while seeking to become Ivy Tech Community College’s new president. Her final day will include being honored in the state Senate, where she is the presiding officer.

The Indiana House and Senate are expected to vote Thursday on confirming former state Republican Party chairman Eric Holcomb as the new lieutenant governor.

The only time since the 1940s a new lieutenant governor was selected in the middle of a term was in 2003 following the death of Gov. Frank O’Bannon.